The Epworth Physical Laboratory was dedicated on Monday, June 12, 1916, erected at a cost of $40,000 during the spring term.  The speakers at the dedication that took place in the chapel included President Samuel Dickie, Reverend A. Raymond Johns, Professor Clarence W. Greene, who gave the presentation speech, and Bishop Joseph Hartzell, D.D., LL.D.  Speeches given during the day of dedication ceremonies were "New Field Open to Specially Trained Physics Men" by Harrison M. Randall, Ph.D. from the University of Michigan, "The Detroit Conference" by Reverend Luther Lovejoy, and "Michigan Conference and the College" by Reverend William H. Phelps, D.D.  Professor Greene and his wife were especially lauded for the enormous amount of work and sacrifice that went into the campaign to raise funds for the building.  Raising one half of the funds from the Methodist Church, they sold "brick certificates" for 25 cents to over 500 Epworth Leagues in the state.

On the main floor of the building was located the Mechanics and Heat Laboratory; the Sound and Light Laboratory; the dark room, for optical work; the library of the Department of Physics, and the office of the Professor of Physics.