The tentative lab schedule is shown in the table below. Since lab space and supplies are limited, we will "cycle" through the experiments in small groups--that is, students will divide into three (or two, later on) during the semester. Group 1 will begin with "click chemistry", group 2 will begin with "quantum dots", and group 3 will begin with "Fremy's salt", and so on.
Procedures for the labs and details regarding the assignments will be distributed in class or via email.
|
Week of |
Tuesday |
Thursday |
|
22 January |
Introduction, schedule, lab space, records, etc. NMR review |
NMR spectroscopy |
|
29 January |
NMR spectroscopy |
NMR experiment |
|
5 February |
Mass spectrometry |
MS experiment |
|
12 February |
1/Click chemistry 2/Quantum dots 3/Fremy's salt |
1/Click chemistry 2/Quantum dots 3/Fremy's salt |
|
19 February |
2/Click chemistry |
2/Click chemistry |
|
26 February |
3/Click chemistry |
3/Click chemistry |
|
4 March |
1/Plastic
Antibodies |
1/Plastic
Antibodies |
|
11 March |
SPRING BREAK |
|
|
18 March |
2/Plastic
Antibodies |
2/Plastic
Antibodies |
|
25 March |
3/Plastic
Antibodies 1/Conducting polymer 2/Cis- and trans-platin |
3/Plastic
Antibodies 1/Conducting polymer 2/Cis- and trans-platin |
|
1 April |
a/Metal DNA cleavage agent |
a/Metal
DNA cleavage agent |
|
8 April |
ACS (4/6-4/10) |
a/Metal DNA
cleavage agent b/OEC model complex |
|
15 April |
b/Metal
DNA cleavage agent |
b/Metal
DNA cleavage agent a/OEC model complex |
|
22 April |
b/Metal DNA cleavage agent |
Elkin Isaac |
|
29 April |
all/CV of Mn complexes |
Clean up, check out, course evaluations |
|
Experiments/Assignments |
The duration of experiments and the assignments required for each are indicated below. Unless indicated otherwise, the assignment/report for any experiment is due the Monday after the experiment has been completed.
|
Experiment |
Experiment duration |
Report |
Assignment |
|
NMR spectroscopy: coupling constants and 2D techniques |
1 | x | |
| Mass spectrometry | 1 | x | |
|
Click chemistry |
2 | x | |
|
Quantum dot nanocrystals |
2 | x | |
|
Fremy's salt |
2 |
|
x |
|
Conducting polymer |
2 | x | |
|
Plastic antibodies |
2 | x | |
|
Cis- and trans-platin |
2 | x | |
|
Bioinorganic model complex (OEC) |
4 | x | |
| Metal DNA cleavage agent | 3 | x |
Welcome to Advanced Synthesis! Each of you comes to this course with your own unique background of previous research experience and interests. My goal for this laboratory course is to introduce you to some of the more common and useful techniques in synthetic chemistry and characterization. With new compounds and materials being synthesized each day, the challenge of choosing which compounds to make is mind-boggling, but I have tried to include a large variety of molecules and materials in this course, while at the same time balancing the techniques and concepts you will learn when synthesizing and characterizing each compound. I'm excited about the range of compounds on the docket for this term and I hope you enjoy the course as much as I have enjoyed planning it. In addition to helping you learn new techniques and exciting chemistry, I hope to broaden your interests and captivate your imagination as we study some of the more recent advances in chemical synthesis and material design.
Techniques and topics we will cover include advanced NMR techniques, mass spectrometry, column chromatography, recrystallization, polymer chemistry, molecular imprinting, transition metal complex synthesis, nanomaterials, and heterocyclic chemistry.
Your
grade for this course will be weighted as follows:
20% Laboratory notebook and chemical hygiene
40% Laboratory reports
40% Laboratory assignments
Using
the following scale:
|
4.0 |
100-92 |
|
3.7 |
91-90 |
|
3.3 |
89-88 |
|
3.0 |
87-82 |
|
2.7 |
81-80 |
|
2.3 |
79-78 |
|
2.0 |
77-72 |
|
1.7 |
71-70 |
|
1.3 |
69-68 |
|
1 |
67-60 |
|
0 |
59-0 |
|
Course Materials |
Lab notebook
Goggles
Spectrometric Identification of Organic Compounds, Silverstein
(recommended)
Lab coat (recommended)
MSDS
simpleview software (available on computers in lab)
CRC Handbook of Chemistry and Physics (available in lab)--mp, bp, density,
solubility, optical rotation,
λmax,
crystal form
Chemical Synthesis Center on Sigma-Aldrich
website (search structures, reaction database)
Chemfinder--chemical
and reaction information
Chemsketch--free software for drawing structures
Powerpoint--22 Jan
Powerpoint--24 Jan
Powerpoint--5 Feb
Dr. Amy
B. Bethune
Office Putnam 356
Lab Kresge 370
x0254
abbethune@albion.edu
www.albion.edu/chemistry/abbethune
|
Office Hours |
|
|
Monday |
Tuesday |
Wednesday |
Thursday |
Friday |
|
8-9 |
|
|
|
|
|
|
9-10 |
chem 123 |
research |
chem 123 |
|
chem 123 |
|
10-11 |
|
|
|
|
|
|
11-12 |
chem 123 |
chem 123 |
|
chem 123 |
|
|
12-1 |
chem 356t | chem meeting | chem 356t |
faculty meeting |
|
|
1-2 |
|
chem 321L |
chem 321L |
|
|
|
2-3 |
|
||||
|
3-4 |
|
seminar |
|||
|
4-5 |
|
When I am not teaching or doing research, you can usually find me in my office. I have an open door policy, so please stop by. I enjoy teaching and talking to students, so if there is something that is unclear from class or from your reading, let’s talk about it. If you stop by and I am not available, please call or email me and we can arrange an appointment.
|
Where to Go For Additional Help |
THE
THE
THE
QUANTITATIVE SKILLS CENTER provides a wide range of support to students in many
subject areas. Students are free to drop in for occasional help from trained
student tutors or to make appointments for on-going tutorial sessions. QSC
staff are available to assist you with the use of mathematics, statistics,
spreadsheets, or graphing calculators in any course. The center also offers
workshops on topics such as partial derivatives in chemistry and preparing for
graduate school exams. For more information, contact the QSC Director, Karla
McCavit, (x0824;
kmccavit@albion.edu).
THE WRITING
CENTER provides trained peer consultants prepared to work with writers at every
stage of the writing process--from getting started brainstorming to writing
drafts, and from organizing ideas to revising or final editing. Writing
consultants support students by responding to writing in process, not by
proofreading, editing, or writing students' papers. Both drop-in tutoring and
scheduled appointments are available during the